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Direct linkCelerier, Aurelie; Pierard, Christophe; Rachbauer, Dagmar; Sarrieau, Alain; Beracochea, Daniel – Learning & Memory, 2004
The present study was aimed at simultaneously determining on the same subject, the effects of stress on retrieval of flexible (contextual or temporal) or stable (spatial) information. Three behavioral paradigms carried out in a four-hole board were designed as follows: (1) Simple Discrimination (SD), in which mice learned a single discrimination;…
Descriptors: Animals, Anxiety, Models, Discrimination Learning
Rhodes, Sarah E. V.; Kilcross, Simon – Learning & Memory, 2004
The prefrontal cortex (PFC) has a well-established role in the inhibition of inappropriate responding, and evidence suggests that the infralimbic (IL) region of the rat medial PFC (MPFC) may be involved in some aspects of extinction of conditioned fear. MPFC lesions including, but not those sparing the IL cortex increase spontaneous recovery of…
Descriptors: Neurological Impairments, Neurological Organization, Brain, Behavioral Science Research
Janus, Christopher – Learning & Memory, 2004
TgCRND8 mice represent a transgenic mouse model of Alzheimer's disease, with onset of cognitive impairment and increasing amyloid-[beta] plaques in their brains at 12 weeks of age. In this study, the spatial memory in 25- to 30-week-old TgCRND8 mice was analyzed in two reference and one working memory Morris water maze (MWM) tests. In reference…
Descriptors: Pathology, Nonverbal Learning, Spatial Ability, Learning Strategies
Hebda-Bauer, Elaine K.; Watson, Stanley J.; Akil, Huda – Learning & Memory, 2005
The impact of a previously successful or unsuccessful experience on the subsequent acquisition of a related task is not well understood. The nature of past experience may have even greater impact in individuals with learning deficits, as their cognitive processes can be easily disrupted. Mice with a targeted disruption of the [alpha] and [delta]…
Descriptors: Memory, Learning Experience, Intervals, Animals
Chudasama, Yogita; Dalley, Jeffrey W.; Nathwani, Falgyni; Bouger, Pascale; Robbins, Trevor W. – Learning & Memory, 2004
Two experiments examined the effects of reductions in cortical cholinergic function on performance of a novel task that allowed for the simultaneous assessment of attention to a visual stimulus and memory for that stimulus over a variable delay within the same test session. In the first experiment, infusions of the muscarinic receptor antagonist…
Descriptors: Aging (Individuals), Visual Stimuli, Short Term Memory, Attention
Vuckovich, Joseph A.; Semel, Mara E.; Baxter, Mark G. – Learning & Memory, 2004
A recent study suggests that lesions to all major areas of the cholinergic basal forebrain in the rat (medial septum, horizontal limb of the diagonal band of Broca, and nucleus basalis magnocellularis) impair a spatial working memory task. However, this experiment used a surgical technique that may have damaged cerebellar Purkinje cells. The…
Descriptors: Neurological Impairments, Animals, Short Term Memory, Spatial Ability
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