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Direct linkCheng, Jingjun; Feenstra, Matthijs G. P. – Learning & Memory, 2006
Combined activation of dopamine D1- and NMDA-glutamate receptors in the nucleus accumbens has been strongly implicated in instrumental learning, the process in which an individual learns that a specific action has a wanted outcome. To assess dopaminergic activity, we presented rats with two sessions (30 trials each) of a one-lever appetitive…
Descriptors: Rewards, Biochemistry, Nonverbal Learning, Animals
Hellweg, Rainer; Huber, Roman; Kuhl, Alexander; Riepe, Matthias W.; Lohmann, Peter – Learning & Memory, 2006
Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease(AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse…
Descriptors: Neurological Impairments, Nonverbal Learning, Correlation, Memory
Sandi, Carmen; Cordero, M. Isabel; Merino, Jose J.; Kruyt, Nyika D.; Regan, Ciaran M.; Murphy, Keith J. – Learning & Memory, 2004
The polysialylated neural cell adhesion molecule (PSA-NCAM) has been implicated in activity-dependent synaptic remodeling and memory formation. Here, we questioned whether training-induced modulation of PSA-NCAM expression might be related to individual differences in spatial learning abilities. At 12 h posttraining, immunohistochemical analyses…
Descriptors: Memory, Slow Learners, Correlation, Neurological Organization
Celerier, Aurelie; Pierard, Christophe; Rachbauer, Dagmar; Sarrieau, Alain; Beracochea, Daniel – Learning & Memory, 2004
The present study was aimed at simultaneously determining on the same subject, the effects of stress on retrieval of flexible (contextual or temporal) or stable (spatial) information. Three behavioral paradigms carried out in a four-hole board were designed as follows: (1) Simple Discrimination (SD), in which mice learned a single discrimination;…
Descriptors: Animals, Anxiety, Models, Discrimination Learning
