A set of common-acting iron-responsive 5'untranslated region (5'UTR) motifs can fold into RNA stem loops that appear significant to the biology of cognitive declines of Parkinson's disease dementia (PDD), Lewy body dementia (LDD), and Alzheimer's disease (AD). Neurodegenerative diseases exhibit perturbations of iron homeostasis in defined brain…

Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice…

Equating of psychometric scales and tests is frequently required and conducted in educational, behavioral, and clinical research. Construct comparability or equivalence between measuring instruments is a necessary condition for making decisions about linking and equating resulting scores. This article is concerned with a widely applicable method…

Alzheimer's disease is a progressive neurodegenerative disorder characterized by amyloid plaques, synapse dysfunction, and memory loss. The production and accumulation of A[beta] peptides, a major component of the amyloid plaques, is sensitive to many genetic and environmental factors. Recently, research has focused on the role of oxidative stress…

This article considers how intergenerational arts can help support the resilience of people living with dementia. Theorising a moment of process from Magic Me's "Reflections of Stepney," it analyses how art facilitators help a child and care home resident to overcome the challenge of relating and create a performance together. It…

Biased sampling occurs frequently in economics, epidemiology, and medical studies either by design or due to data collecting mechanism. Failing to take into account the sampling bias usually leads to incorrect inference. We propose a unified estimation procedure and a computationally fast resampling method to make statistical inference for…

The use of comics can be a powerful tool to expand educational outreach efforts for improving the health and well-being of people everywhere. Dr. Ian Williams coined the term "graphic medicine" to denote the use of comics in medical education and patient care ("Graphic Medicine"). Alzheimer's disease affects approximately five…

This article explores the representation of disability and academic identity in two award-winning films: "Still Alice" and "The Theory of Everything." Drawing on scholarship about embodiment and the 'normal professor body', I demonstrate how the complex images of disabled academics in these films take up and replicate (to…

Through the perspectives of a museum educator, an art educator, and an educational researcher, this article explores the evolution of shared definitions of "well-being" in the development of a museum- and arts-based program for adults with Alzheimer's disease and related dementias (ADRD). By piecing together the authors' first-person…

This article describes the healing benefits of art therapy for an individual with dementia of the Alzheimer's type. In this clinical case description, a woman diagnosed with Alzheimer's disease received individual art therapy for 17 weeks. The treatment concerns that arose, altered view of reality, agitation, and retrogenesis provide insight on…

"Toxoplasma gondii" is a protozoan parasite that infects about a third of human population. It is generally believed that in immunocompetent hosts, the parasite infection takes usually asymptomatic course and induces self-limiting disease, but in immunocompromised individuals may cause significant morbidity and mortality. "T. gondii" uses sulfated…

This article draws attention to the fact that documentaries do not simply reproduce the reality that film and audience share but always present a particular view of this reality. This implies that organizations in Alzheimer care, education, and research that often recommend documentaries to inform people about dementia should take into account…

Alzheimer's disease (AD) can impair metacognition in addition to more basic cognitive functions like memory. However, while global metacognitive inaccuracies are well documented (i.e., low deficit awareness, or anosognosia), the evidence is mixed regarding the effects of AD on local or task-based metacognitive judgments. Here we investigated local…

Propositional analysis of text, including the generation of proposition density ratios, is examined within the context of Alzheimer's research. A discussion of linguistic modularity raises questions regarding the outcomes of propositional analysis and its applications in Alzheimer's research. (Contains 1 figure.)

As America ages, greater numbers of older adults will be living with Alzheimer's disease or a related dementia, leading to increased incidence of wandering. Currently there are several initiatives to assist older adults who go missing. We describe and critically examine three prominent and widespread programs: Safe Return, Project Lifesaver, and…