In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the "NT-3" gene is deleted in the brain, we investigated the role of NT-3 in adult neurogenesis, hippocampal plasticity, and memory. Bromodeoxyuridine…

Background: Very little is known about the neuropsychological correlates of adaptive functioning in people with intellectual disabilities (ID). This study examined whether specific cognitive deficits and demographic variables predicted everyday functioning in adults with ID. Method: People with ID (n = 101; ages 19-41 years; mean education = 11…

Infants represent the acts of others and their own acts in commensurate terms. They can recognize cross-modal equivalences between acts they see others perform and their own felt bodily movements. This recognition of self-other equivalences in action gives rise to interpreting others as having similar psychological states such as perceptions and…

The study examined brain functions related to information processing in autistic adults using auditory evoked potentials (AEP) and missing stimulus potentials (MSP). Both nonautistic and autistic adults showed normal mature patterns and lateralities in AEP for music stimuli, but nonautistic children did not. Autistic adults showed matured patterns…

Linguistic processing by the left and right cerebral hemispheres was investigated in 10 adult stutterers and 10 matched nonstutterers. The stuttering group exhibited a left visual field efficiency or right hemisphere preference for this task and were slower in both vocal and manual reaction times. (Author/CL)

The study reports a cluster analysis of Luria-Nebraska Neuropsychological Battery sources of 25 learning disabled adults. The cluster analysis suggested the presence of three subgroups within this sample, one having high elevations on the Rhythm, Writing, Reading, and Arithmetic Rhythm scales, the second having an extremely high evelation on the…

Purpose: Corticomuscular electroencephalographic-electromyographic (EEG-EMG) coherence elicited by speech and nonspeech oromotor tasks in healthy participants and those with Parkinson's disease (PD) was examined. Hypotheses were the following: (a) corticomuscular coherence is demonstrable between orbicularis oris (OO) muscles' EMG and scalp EEG…

Fifteen aphasic and 15 normal adults demonstrated use of a right hemisphere visuospatial strategy to analyze printed whole words and word parts such as prefixes and suffixes. The performances of the two groups were similar, suggesting that the hypothesized strategy could be useful as a reading approach for aphasics. (Author/CL)

Evidence gathered from commissurotomy (split-brain) patients and right-hemisphere/left-hemisphere studies on normal intact humans is reviewed and evaluated. Concludes that right-left hemisphere differences reported in normal subjects are small and that there is no scientific basis for any reorganization of curricular, teaching, or testing…

The study assessed how unilateral right hemisphere brain damage (RHD) affects processing of metaphoric aspects of word meaning. RHD stroke patients (N=25) performed similarly to left-brain-damaged and normal subjects in the automatic condition and when provided with processing strategies. Both brain-damaged groups had difficulty developing…

This review discusses how general principles of brain development have contributed to both human brain plasticity and the acquisition of the human capacity for speech. Specifically, the role played by plastic developmental processes in the evolution and development of articulate control over vocalization in speech is examined. (Contains…

In an investigation using auditory evoked responses (AERs) to compare strongly left- and strongly right-handed adults in their hemispheric processing of speech materials, it was anticipated that AERs would reflect a bilateralization in the left-handed group of subjects and marked hemispheric differences in the right-handed group. In addition, the…

An irrelevant auditory probe procedure was employed to evoke brain event-related potentials (ERPs) in 56 right-handed Caucasian males while they learned concepts presented to them in study booklets. A mastery test was administered to assess concept acquisition. Subjects were divided into two groups according to whether or not their achievement…

In a previous functional magnetic resonance imaging (fMRI) study we demonstrated an involvement of the medial temporal lobe (MTL) during an implicit learning task. We concluded that the MTL was engaged because of the complex contingencies that were implicitly learned. In addition, the basal ganglia demonstrated effects of a paralleled…

Our facial expressions give others the opportunity to access our feelings, and constitute an important nonverbal tool for communication. Many recent studies have investigated emotional perception in adults, and our knowledge of neural processes involved in emotions is increasingly precise. Young children also use faces to express their internal…