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Prospective Study of the Prevalence of Alzheimer-Type Dementia in Institutionalized Individuals with Down Syndrome.
Visser, F. E.; And Others – American Journal on Mental Retardation, 1997
Institutionalized patients with Down syndrome (N=307) were monitored for 5 to 10 years to determine prevalence of Alzheimer-type dementia. Prevalence increased from 11% between ages 40 and 49 to 77% between 60 and 69. All patients 70 and over had dementia. Mean age of onset of dementia was 56 years. Neuropathological findings were consistent with…
Descriptors: Adults, Alzheimers Disease, Clinical Diagnosis, Downs Syndrome
Dementia in Adults with Down Syndrome: Diagnostic Challenges.
Burt, Diana B.; Loveland, Katherine A.; Primeaux-Hart, Sharon; Chen, Yuan-Who; Phillips, Nathalie Breen; And Others – American Journal on Mental Retardation, 1998
This report describes the status of 70 adults (ages 22 to 60 at the longitudinal study's beginning) with Down syndrome who are being followed for signs of dementia. After 10 years, 12 met all criteria for dementia, 40 met subsets of criteria, and 18 met no criteria. Information is provided on choice and revision of instruments and dementia…
Descriptors: Adults, Alzheimers Disease, Clinical Diagnosis, Downs Syndrome
Onset of Dyspraxia in Aging Persons with Down Syndrome: Longitudinal Studies.
Peer reviewed Peer reviewed
Dalton, Arthur J.; Fedor, Bettye L. – Journal of Intellectual and Developmental Disability, 1998
Because dyspraxia (partial loss of the ability to perform purposeful motor acts) is an early symptom of Alzheimer disease, a 62-item dyspraxia scale adapted for adults with Down syndrome (DS) was developed. Use of the measure over 3.5 years with 72 DS individuals (age 40 or older) found statistically significant deterioration that suggested…
Descriptors: Adults, Aging (Individuals), Alzheimers Disease, Downs Syndrome
Aspects of Cognitive Functioning in Adults with Intellectual Disabilities
Peer reviewed Peer reviewed
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Perkins, Elizabeth A.; Small, Brent J. – Journal of Policy and Practice in Intellectual Disabilities, 2006
Recently, more attention is being given to identifying aging-related and dementia-related pathological changes in performance and cognition among persons with intellectual disabilities (ID). This literature review examines age-related differences in specific aspects of cognitive functioning and cognitive performance of people with ID and…
Descriptors: Mental Retardation, Alzheimers Disease, Dementia, At Risk Persons
Age, Adaptive Behavior, and Alzheimer Disease in Down Syndrome: Cross-Sectional and Longitudinal Analyses.
Rasmussen, Dianne E.; Sobsey, Dick – American Journal on Mental Retardation, 1994
Cross-sectional and longitudinal analyses compared age-related changes in adaptive functioning in institutionalized adults with and without Down's syndrome. Cross-sectional analysis showed significant differences related to level of functioning but not to age or etiology. Longitudinal analysis showed a decline in self-help and communication skills…
Descriptors: Adaptive Behavior (of Disabled), Adults, Aging (Individuals), Alzheimers Disease
Language in Ageing Persons with Down Syndrome.
Peer reviewed Peer reviewed
Rondal, Jean A.; Comblain, Annick – Down Syndrome Research and Practice, 2002
Several cross-sectional studies and one longitudinal study were conducted on the language abilities of various cohorts of persons with Down syndrome (ages 14-50). A gradual decrease in global cerebral metabolic rate (CMR) for both hemispheres and for each participant was documented, however, no language deterioration could be associated with CMR…
Descriptors: Adults, Age Differences, Alzheimers Disease, Brain Hemisphere Functions