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Prashner, V. P.; Chowdhury, T. A.; Rowe, B. R.; Bain, S. C. – American Journal on Mental Retardation, 1997
ApoE gene polymorphism was examined in 100 adults with Down syndrome with and without dementia (Alzheimer's disease) and 346 control subjects. Additionally, a meta analysis of studies (total N=480 subjects) was performed. Results indicated a similar incidence of the gene across groups but subjects with the allele tended to an earlier onset of…
Descriptors: Adults, Age Differences, Alzheimers Disease, Downs Syndrome