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Prashner, V. P.; Chowdhury, T. A.; Rowe, B. R.; Bain, S. C. – American Journal on Mental Retardation, 1997
ApoE gene polymorphism was examined in 100 adults with Down syndrome with and without dementia (Alzheimer's disease) and 346 control subjects. Additionally, a meta analysis of studies (total N=480 subjects) was performed. Results indicated a similar incidence of the gene across groups but subjects with the allele tended to an earlier onset of…
Descriptors: Adults, Age Differences, Alzheimers Disease, Downs Syndrome
Peer reviewedDas, J. P.; Mishra, Rama K. – Research in Developmental Disabilities, 1995
Comparison of cognitive processes in 23 individuals with Down's syndrome (DS) and 23 individuals of comparable mental handicap without Down's syndrome found that older (above 40 years) DS subjects had significantly poorer outcomes. The areas of speech rate, number finding, and expressive attention appeared to show the earliest signs of dementia of…
Descriptors: Adults, Age Differences, Aging (Individuals), Alzheimers Disease
Visser, F. E.; And Others – American Journal on Mental Retardation, 1997
Institutionalized patients with Down syndrome (N=307) were monitored for 5 to 10 years to determine prevalence of Alzheimer-type dementia. Prevalence increased from 11% between ages 40 and 49 to 77% between 60 and 69. All patients 70 and over had dementia. Mean age of onset of dementia was 56 years. Neuropathological findings were consistent with…
Descriptors: Adults, Alzheimers Disease, Clinical Diagnosis, Downs Syndrome
Peer reviewedRondal, J. A.; Elbouz, M.; Ylieff, M.; Docquier, L. – Down Syndrome Research and Practice, 2003
This paper reports on a 15-year follow-up of the linguistic and cognitive profile of a woman with standard trisomy 21 (Down syndrome). The follow-up found recent rapid deterioration in receptive and productive language skills. However, basic phonological and morphosyntactic skills are preserved. Her changing profile mirrors that found in aging…
Descriptors: Adults, Aging (Individuals), Alzheimers Disease, Case Studies
Zigman, Warren B.; And Others – American Journal on Mental Retardation, 1996
Comparison of adults with mental retardation either with or without Down syndrome and under or over 50 years of age found a significantly higher rate of dementia only in Down syndrome subjects over 50. However, the observed incidence based on functional findings was substantially below the presumed 100% prevalence of neuropathological markers of…
Descriptors: Adaptive Behavior (of Disabled), Adults, Alzheimers Disease, Daily Living Skills
Rasmussen, Dianne E.; Sobsey, Dick – American Journal on Mental Retardation, 1994
Cross-sectional and longitudinal analyses compared age-related changes in adaptive functioning in institutionalized adults with and without Down's syndrome. Cross-sectional analysis showed significant differences related to level of functioning but not to age or etiology. Longitudinal analysis showed a decline in self-help and communication skills…
Descriptors: Adaptive Behavior (of Disabled), Adults, Aging (Individuals), Alzheimers Disease
