The association between attributional style (AS), problem-solving orientation (PSO), and gender on depressive symptoms was investigated in Egyptian adolescents with visual impairment (VI). After being written in Braille, measures of AS, PSO, and depression were administered to 110 adolescents with VI, ages 12-17 years, from a residential school for pupils with VI. Regression analyses showed that gender, negative general (NG) attributions, and negative problem-solving orientation (NPSO) were the strongest predictors of depressive symptoms in adolescents with VI, whereas negative internal (NI) attributions and avoidant problem-solving orientation (APSO) were weak predictors. The findings are discussed in relation to different perspectives and models of depression, particularly the stress-diathesis model. The theory that these cognitive variables are core constituents of a cognitive diathesis model of depression in individuals with VI is not supported by this study. (Contains 3 tables.)