The last decade has seen an exponential increase in the use of illicit and prescription opioids during pregnancy. Opioid dependency during pregnancy increases the risks of obstetric complications for mothers and potential dangers for newborns during infancy and later in life. The mother-child dyad faces specific hurdles when it comes to getting their medical and psychosocial needs met. The purpose of this article is to identify gaps in care of families affected by opiate abuse and review how the Mother and Child Dependency Program at the MetroHealth System in Cleveland, Ohio, is trying to bridge these gaps through comprehensive, multidisciplinary, and standardized treatment for this vulnerable population.