In the era of 21st century learning, many secondary students with learning disabilities continue to struggle with mathematics problem solving. Emerging evidence suggests self-regulated strategy development can be combined with existing evidence-based and promising practices during mathematics instruction. These practices include explicit instruction, metacognition, use of visual representations, ongoing formative assessment and feedback, multiple examples, and self-regulation. We describe the promising and practical potential of SRSD and STAR, a research-based, metacognitive problem-solving strategy, for instruction in algebraic problem-solving. A practical example is provided to illustrate the combination of practices.