This study investigates the factors influencing perceptions of air quality in the industrial city of Hamilton, Canada. The research employs data collected via a telephone survey of 1,002 adult residents in three neighbourhoods. Perceptions in the neighbourhoods were examined by individual socio-demographic factors (age, gender, marital and immigrant status, education, etc.) in addition to perceived health status and neighbourhood problems (environmental, social and safety concerns). Neighbourhood variations were found, with those residing in the Southwest Mountain neighbourhood being over 6 times more likely to report a "good" perception of air quality than those residing in the Lower City neighbourhood. In addition, factors influencing these perceptions also varied by neighbourhood. Perceived neighbourhood problems strongly influenced perceptions of air quality in the Lower City and Central areas, whereas socio-demographic factors were significant primarily in the Lower City neighbourhood, suggesting the importance of these mediating dimensions; pointing to less of a concern about air quality. There was, however, remarkable consistency in all three neighbourhoods when respondents were asked whether their perception of air quality affected their choice to go outside. Overall, the presence or absence of perceived problems, such as pollution and safety, had a powerful effect on shaping and differentiating neighbourhood responses.