Learning how the periodic table has developed over time can provide an important foundation for students' future science learning, as they begin to explore the explanatory power of other models in science. In this activity, students are given the opportunity to investigate the generation of the modern periodic table, through a process of creating their own plausible periodic tables. In addition, students learn about Mendeleev's contribution and the nature of science through inquiry-based instruction. (Contains 6 figures and 5 resources.)