All too often, subjects in schools present disjointed phenomena as a compilation of data or facts that seem isolated from students' lives. However, current science education pedagogy clearly emphasizes integration of knowledge and skills in real-world settings (NRC 2007). This integrated instructional approach addresses fundamental process skills as described in "A Framework for K-12 Science Education" (NRC 2012). This alignment can be observed in practices 4, 6, 7, and 8 (analysis and interpretation of data, constructing explanations, engaging in argument from evidence, and communicating information). To illustrate this, the authors describe an activity that integrates science and art concepts around the theme of cell organelles, using the exciting and somewhat unusual medium of painted silk batik, which has a "wow" factor of beautiful results beyond typical school-based media. The challenge presented to students in this activity is based on the well-known assumption that abstract thinking supports a better understanding of nature phenomena. (Contains 4 figures, 2 online resources, and an activity worksheet.)