Educational activities are significant in that they have an important place in the life of the individual and support mental health. In this study, the relationship between mindfulness and academic buoyancy and the mediating role of academic hope were examined in a longitudinal research study. Data were collected from 287 Turkish university students who participated in the study at 4-month intervals. An autoregressive analysis of the cross-lagged panel model for a half-longitudinal design was used to test the role of academic hope as a mediator in the relationship between mindfulness and academic buoyancy. The results revealed the direct effect of mindfulness on academic hope and academic buoyancy. In addition, academic hope was found to have a mediating effect on the relationship between mindfulness and academic buoyancy. It was, therefore, concluded that improving mindfulness practices may benefit people from both an academic and spiritual perspective.