Objective: To describe electronic cigarette use among undergraduate college students who self-report feelings of anxiety. Background: Electronic cigarette use, and anxiety are increasing among undergraduate college students. Limited studies have been conducted on electronic cigarette use among college students who self-report feelings of anxiety. Describing the experience of electronic cigarette use and feelings of anxiety will advance our understanding of the phenomenon of electronic cigarette use in this age group. This is particularly important since this group is at increased risk for addiction and mental health disorders, contributing to adverse health consequences. Research Design: A qualitative descriptive study using the Roy Adaptation Model as the theoretical framework explored the phenomenon. Setting: One medium-sized private university with two campuses on the east coast of the United States. Methods: Purposive sampling was used to identify participants who met the study inclusion criteria, which included full-time undergraduate students between 18 and 25 who are proficient in English, self-reported feelings of anxiety, and used electronic cigarettes with nicotine. Data were collected using a demographic questionnaire, smoking status questionnaire, self-report feelings of anxiety questionnaire, and a semi-structured interview guide. Procedure: Interviews were conducted via ZOOM and recorded. Transcripts were analyzed using Miles and Huberman's (1994) framework for qualitative content analysis. Categories, subcategories, and themes were identified. Trustworthiness was established by addressing the credibility, dependability, confirmability, and transferability of the study results. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]