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Abraham, Jayne – ProQuest LLC, 2009
Aged mice exhibit a heightened central inflammatory cytokine response, as well as prolonged hippocampal-dependent cognitive deficits, compared to adults when administered lipopolysaccharide (LPS) to mimic a peripheral infection. The excessive production of inflammatory cytokines such as interleukin (IL)-1[beta] within the brain is proposed to…
Descriptors: Animals, Brain, Neurological Impairments, Nutrition