The chronic underrepresentation of Native and indigenous peoples in STEM fields (Fig. 1) has been a longstanding issue in the United States, despite concentrated efforts by many local and national groups, including the Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) and the American Indian Science and Engineering Society (AISES) to address it. Here we report on the conference on Indigenous Worldviews in Informal Science Education (I-WISE), convened in Albuquerque, NM, on Sept. 2-5, 2015. We share what we learned on the commonalities and differences in perspectives between indigenous knowledge (IK) and Western science; summarize the role that IK is already playing in scientific fields, ranging from astrophysics to medicine to climate change; and describe how IK can help science education and research be more sustainable, inclusive, and respectful to all peoples.