The study assessed the effectiveness of developed comics as strategic intervention material on teaching biology, particularly photosynthesis. The study also determined the attitudes of the students on the use of developed CoSIM. Moreover, the study provided results on the mean difference between the pre test and posttest performance of the students and significant relationship between the level of academic performance and the attitudes when aided by developed strategic intervention materials. In addition, the researchers made used of validated pretest-posttest and attitude survey-questionnaire as the primary tools of the study. The findings showed that the developed comic was effective as strategic intervention material in teaching biology concepts, on photosynthesis. The students have high positive attitude toward the developed CoSIM. There was a significant difference between the pre-test and posttest mean scores of the students. More so, students' academic performance significantly high positive relationship to the students' attitude toward the utilization of CoSIM in teaching biology, particularly photosynthesis. Future utilization of this CoSIM as an strategic instructional material would raise students' academic performance and attitude in teaching specific science concepts.