Interaction is one of the key elements for learning and it also has a significant role in increasing efficiency in e-learning programs. Several studies indicate that high level of learner and content interaction provided by e-learning programs brings learner satisfaction and achievement. During the learning process, content interaction provides an effective means to reach learning goals. Successful content design and adequate content interaction items are essential to sustain attention, provide motivation, achieve high levels of satisfaction of learning and provide significant increase in learning performance. In this study, perception and expectation of 236 e-learners are examined to observe the outcomes of content design in learning. The items required for content interaction are classified under three main topics as Attention-Motivation, Satisfaction and Learning Performance. The research model is based on how efficient design of these items helps to increase learner and content interaction. The increase of interaction will result in learner achievement. Therefore, the efficiency of the e-learning process will correlate with higher levels of learner-content interaction. Adequate and efficient content design contributes to effective learning.