The under-representation of females in Information and Communication Technology (ICT) fields of study and careers continues to attract considerable attention. This article discusses findings of a research that investigated interest in ICT studies and careers among female secondary school students from schools in three districts in the Central Region of Ghana. The article outlines the demographic background of the participating girls, their experiences with ICT, and their preferences for future studies and careers in ICT. Engineering was the least preferred career choice among female science students in coeducational schools whilst Computer Science/ICT and Nursing were the least preferred career choice among science students in female only schools. However, Medicine was the most preferred career choice among students of both types of schools. [This paper was published in the "Ghana Journal of Education and Teaching," No. 12 (2011).] (Contains 4 tables.)