This paper presents a novel school-based intervention programme for children with chronic and severe emotional and behavioural difficulties. The main aim of the programme is to reduce conduct problems and to increase prosocial behaviours. The ultimate aim of such a programme is to help pupils with severe and chronic conduct problems back on track to mainstream education. The programme was developed based on basic science findings, including recent neuroscience work on children with elevated levels of callous-unemotional (CU) traits. This programme also aims to feedback into the research base by examining how CU contributes toward conduct problems in the classroom and how far it is possible to reduce CU traits as well as conduct problems.