NotesFAQContact Us
Collection
Advanced
Search Tips
Showing all 6 results Save | Export
Age-Dependent Attenuation of Spatial Memory Deficits by the Histone Acetyltransferase P300/CBP-Associated Factor (PCAF) in 3XTG Alzheimer's Disease Mice
Peer reviewed Peer reviewed
Direct linkDirect link
Creighton, Samantha D.; Jardine, Kristen H.; Desimone, Alexa; Zmetana, Megan; Castellano, Sabrina; Milite, Ciro; Sbardella, Gianluca; Winters, Boyer D. – Learning & Memory, 2022
Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional…
Descriptors: Alzheimers Disease, Animals, Research, Spatial Ability
Young APOE[subscript 4] Targeted Replacement Mice Exhibit Poor Spatial Learning and Memory, with Reduced Dendritic Spine Density in the Medial Entorhinal Cortex
Peer reviewed Peer reviewed
Direct linkDirect link
Rodriguez, Gustavo A.; Burns, Mark P.; Weeber, Edwin J.; Rebeck, G. William – Learning & Memory, 2013
The apolipoprotein E4 ("APOE-[epsilon]4") allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, and may predispose individuals to Alzheimer's-related cognitive decline by affecting normal brain function early in life. To investigate the impact of human APOE alleles on cognitive performance in mice, we trained…
Descriptors: Animals, Spatial Ability, Memory, Biochemistry
Restoration of Dopamine Release Deficits during Object Recognition Memory Acquisition Attenuates Cognitive Impairment in a Triple Transgenic Mice Model of Alzheimer's Disease
Peer reviewed Peer reviewed
Direct linkDirect link
Guzman-Ramos, Kioko; Moreno-Castilla, Perla; Castro-Cruz, Monica; McGaugh, James L.; Martinez-Coria, Hilda; LaFerla, Frank M.; Bermudez-Rattoni, Federico – Learning & Memory, 2012
Previous findings indicate that the acquisition and consolidation of recognition memory involves dopaminergic activity. Although dopamine deregulation has been observed in Alzheimer's disease (AD) patients, the dysfunction of this neurotransmitter has not been investigated in animal models of AD. The aim of this study was to assess, by in vivo…
Descriptors: Alzheimers Disease, Animals, Recognition (Psychology), Patients
The Anaphase Promoting Complex Is Required for Memory Function in Mice
Peer reviewed Peer reviewed
Direct linkDirect link
Kuczera, Tanja; Stilling, Roman Manuel; Hsia, Hung-En; Bahari-Javan, Sanaz; Irniger, Stefan; Nasmyth, Kim; Sananbenesi, Farahnaz; Fischer, Andre – Learning & Memory, 2011
Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The…
Descriptors: Animals, Posttraumatic Stress Disorder, Alzheimers Disease, Diseases
GAP-43 Gene Expression Regulates Information Storage
Peer reviewed Peer reviewed
Direct linkDirect link
Holahan, Matthew R.; Honegger, Kyle S.; Tabatadze, Nino; Routtenberg, Aryeh – Learning & Memory, 2007
Previous reports have shown that overexpression of the growth- and plasticity-associated protein GAP-43 improves memory. However, the relation between the levels of this protein to memory enhancement remains unknown. Here, we studied this issue in transgenic mice (G-Phos) overexpressing native, chick GAP-43. These G-Phos mice could be divided at…
Descriptors: Animals, Alzheimers Disease, Memory, Animal Behavior
Spatial Navigation in Complex and Radial Mazes in APP23 Animals and Neurotrophin Signaling as a Biological Marker of Early Impairment
Peer reviewed Peer reviewed
Direct linkDirect link
Hellweg, Rainer; Huber, Roman; Kuhl, Alexander; Riepe, Matthias W.; Lohmann, Peter – Learning & Memory, 2006
Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease(AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse…
Descriptors: Neurological Impairments, Nonverbal Learning, Correlation, Memory