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Fujiwara, Hiroki3
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Yamazaki, Yoshihiko3
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Synaptic Plasticity in Hippocampal CA1 Neurons of Mice Lacking Inositol-1,4,5- Trisphosphate Receptor-Binding Protein Released with IP[subscript 3] (IRBIT)
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Goto, Jun-Ichi; Fujii, Satoshi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko; Yamazaki, Yoshihiko – Learning & Memory, 2022
In hippocampal CA1 neurons of wild-type mice, a short tetanus (15 or 20 pulses at 100 Hz) or a standard tetanus (100 pulses at 100 Hz) to a naive input pathway induces long-term potentiation (LTP) of the responses. Low-frequency stimulation (LFS; 1000 pulses at 1 Hz) 60 min after the standard tetanus reverses LTP (depotentiation [DP]), while LFS…
Descriptors: Animals, Brain Hemisphere Functions, Stimuli, Neurology
Depotentiation Depends on IP[subscript 3] Receptor Activation Sustained by Synaptic Inputs after LTP Induction
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Fujii, Satoshi; Yamazaki, Yoshihiko; Goto, Jun-ichi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko – Learning & Memory, 2020
In CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1 synapses, and was reversed by the delivery of a train of low-frequency stimulation (LFS, 1000…
Descriptors: Brain, Animals, Brain Hemisphere Functions, Stimuli
Prior Activation of Inositol 1,4,5-Trisphosphate Receptors Suppresses the Subsequent Induction of Long-Term Potentiation in Hippocampal CA1 Neurons
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Fujii, Satoshi; Yamazaki, Yoshihiko; Goto, Jun-Ichi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko – Learning & Memory, 2016
We investigated the role of inositol 1,4,5-trisphosphate receptors (IP3Rs) activated by preconditioning low-frequency afferent stimulation (LFS) in the subsequent induction of long-term potentiation (LTP) in CA1 neurons in hippocampal slices from mature guinea pigs. Induction of LTP in the field excitatory postsynaptic potential or the population…
Descriptors: Conditioning, Stimulation, Neurological Organization, Brain Hemisphere Functions