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Direct linkRodriguez, Gustavo A.; Burns, Mark P.; Weeber, Edwin J.; Rebeck, G. William – Learning & Memory, 2013
The apolipoprotein E4 ("APOE-[epsilon]4") allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, and may predispose individuals to Alzheimer's-related cognitive decline by affecting normal brain function early in life. To investigate the impact of human APOE alleles on cognitive performance in mice, we trained…
Descriptors: Animals, Spatial Ability, Memory, Biochemistry
