The COVID-19 pandemic has created significant challenges for informal health science education, which traditionally involves face-to-face programming. We describe the adaptation of hands-on environmental health science kits for online and socially distanced informal education with diverse audiences. These hands-on science kits were traditionally used for in-person, whole group instruction. Because the kits include all the materials needed to complete the activities, they provide hands-on science experiences without the need for a science lab facility. We developed a logistics plan for online use of the kits, taking into account the use of technology, kit distribution, virtual instruction, and audience engagement. We also developed COVID-19-safe practices for in-person instruction that supported social distancing while engaging learners in hands-on science. The strategic adaptation and creative implementation of these kits allowed us to engage our community's youth in environmental health learning during the isolated and uncertain times of the pandemic. Lessons learned from this experience may inform future efforts to provide remote, interactive informal science education to respond to diverse learners' needs.