A multistep synthesis of a novel arylidene 3­(2"H")-furanone has been designed and optimized for the second-year organic laboratory. The three-step sequence consists of a nucleophilic substitution, intramolecular cyclization, and acid-catalyzed aldol condensation, and can be carried out within two 3 h laboratory periods. The final…

Using crystal structure data, site directed mutagenesis, and real-time kinetic assays, students designed, expressed, and purified engineered mutants of human insulin-degrading enzyme (IDE). Students designed their own IDE mutants following "in silico" analysis, used inverse PCR to generate mutant plasmid expression constructs, expressed…

Raman scattering is a powerful tool for revealing the vibrations of molecules, but as a nonlinear optical phenomenon, its signals can change via mechanisms like resonance enhancement that have no direct analogue in infrared spectroscopy. In this work, complementary measurements conducted on 4-nitrophenol and its conjugate base allow students to…

Analysis of results from research in cognitive science and discipline-based education in recent years suggests that student thinking and learning can be better understood and investigated by adopting a systemic perspective that recognizes the complex and dynamic interactions taking place within and across multiple interconnected and interdependent…

Surface chemistry is a challenging realm for most students because of its abstract nature and numerous associated mathematical equations. Herein we report a set of dedicated sequential inquiry-based learning (IBL) activities enriched with virtual laboratory learning and hands-on instructions. The activities were intended to help students grasp…

A laboratory experiment that exposes students to fundamental concepts in kinetics and statistical thermodynamics to study systems of great current interest in nanotechnology by employing a foundational technique in physical chemistry is described. A modified commercial flash photolysis spectrometer was used to study photoinduced isomerization…

Crystal materials are an important pillar of advanced technology. Among them, the preparation of large-sized single crystal materials is of great importance for their practical application. Herein, we select the well-known nonlinear optical crystal KH[subscript 2]PO[subscript 4] and impressive deep-blue colored crystal CuSO[subscript…

A laboratory experiment was developed for the continuous flow preparation of an aminal derived from the condensation of furfural with morpholine. The experiment introduces the students to concepts of green chemistry, heterogeneous catalysis, and continuous flow. A cheap and easy setup allows the heterogeneous catalyst reactor to be built in class.…

In an effort to further develop critical thinking and problem solving skills, a guided-inquiry-based, multioutcome organic chemistry synthesis and characterization experiment was developed. Students were provided with the protocol for a time-saving microwave-assisted acetanilide synthesis reaction from acetic anhydride and an unknown primary aryl…

A national survey of chemists (n = 174) explored the self-reported format and focus of postsecondary inorganic chemistry instructional laboratory curricula. Multiple instructional laboratory course formats were observed, including stand-alone inorganic chemistry instructional laboratory courses, inorganic chemistry laboratory instruction as a…

The formation of chemical patterns is in general difficult to control due to the random diffusive motions of the reacting chemical species in solution. In this paper, we present a new method using audible sound to control the formation of chemical patterns obtained in blue bottle experiments. The waves generated on the surface of the solution by…

Preparative chromatography is one of the most common and important purification techniques in organic chemistry and is employed in laboratories across the globe. In order to facilitate student proficiency with the method, a unique approach for the separation of estragole, ethyl cinnamate, and cinnamyl alcohol using microscale preparative flash…

We describe here a 4 hour experimental session based on reaction monitoring of the degradation of an organic pollutant via a Fenton-like reaction. An aqueous solution of p-nitrophenol is treated with hydrogen peroxide and magnetite, and the progress of the reaction is monitored by UV-vis spectrophotometry and/or gas chromatography using an…

A straightforward protocol for the preparation of the colorful and air-stable diphenyl ditelluride is described. In one laboratory session, students isolate their product and characterize it via melting point determination, mass spectrometry, and NMR spectroscopy ([superscript 1]H, [superscript 13]C­{[superscript 1]H}, and [superscript…

In this laboratory experiment, first-semester organic chemistry students use mechanistic reasoning to propose possible outcomes for the reaction of vanillin isobutyrate with a hydride source. The students subsequently run the reaction, isolate the product, and acquire its infrared spectrum. The experiment provides students with the opportunity to…