The influence of vocational interest, self-efficacy beliefs, and academic achievement on choice of educational pathway is described for a cohort of Australian students. Participants were 189 students aged 14-15 years, who were considering either academic or applied learning pathways and subject choices for the final 3 years of secondary school. Using Holland's interest model within a social cognitive career theory (SCCT) framework, logistic regression analyses indicated that all three constructs were significant predictors of pathway and subject selection and enrolment. The best predictive model for students with strong Realistic interests was an interaction of self-efficacy and interest. For Investigative students, both self-efficacy and achievement were best predictors and for Artistic, Social, and Conventional, achievement was the best predictor of future course enrolment. The results of this research offer partial support for the theory of Lent, Brown, and Hackett in that a variable pattern of associations between vocational interest, self-efficacy, and achievement emerged across the Holland interest themes. (Contains 4 tables.)