Three social contexts--family, neighborhood youth centers, and peer relationships--were examined in relation to several measures of adjustment among 1,406 mostly minority, inner-city adolescents. Family and center involvement were directly related to 3 of the 4 adjustment measures (i.e., achievement orientation, emotion regulation, attitudes toward school). Peer connections interacted with family and center involvement to also predict these variables. Substance use, the fourth adjustment measure, was related only to family involvement. Significant 3-way interactions suggested that within urban settings, favorable attitudes toward school may best be achieved when family, neighborhood youth center, and peer involvement are all strong. The combined effects of these 3 contexts appear to be greater among younger adolescents. Implications for promoting urban youth development programs are discussed.