Over the last five years, Puerto Rico has faced fiscal and economic disruptions, demographic shifts, hurricanes and earthquakes, governance challenges, and the ongoing COVID-19 pandemic. While most of these conditions are not new to Puerto Rico, the intersection of all these challenges created a nexus for institutional resilience and efforts. This brief is the second phase of a multi-tiered project--the first of which was an environmental scan of conditions and context of the population, K-12 educational pipeline, higher education, and workforce in Puerto Rico that "Excelencia" published in 2021. While this brief is not meant to be exhaustive of the experiences of institutions and students in Puerto Rico, it is indicative in a broader sense of institutional resilience and transformation to meet their mission and goals to serve their communities with a quality education. "Excelencia" in Education engaged five Puerto Rican HSIs in a series of interviews to learn more about their efforts in resilience in the last five years: (1) Inter American University of Puerto Rico-Arecibo; (2) Universidad Ana G. Méndez-Gurabo; (3) University of Puerto Rico-Mayagüez; (4) University of Puerto Rico-Río Piedras; and (5) University of Puerto Rico-Utuado. [For the environmental scan report, "Higher Education in Puerto Rico: Conditions and Context Influencing Institutional Resilience," see ED614617.]