Finger gnosia and fine motor skills (FMS) are assumed to play a key role in the development of arithmetic abilities, but their contribution to early numerical skills (i.e., enumeration skills and cardinality) has received little attention so far. The purpose of this study was to investigate the predictive value of finger gnosia and FMS to enumeration, cardinal, and arithmetical abilities and how these different dimensions contribute to arithmetic development. Overall, 3- to 5-year-old preschoolers were asked to perform tasks assessing enumeration, cardinality, and early arithmetic, as well as finger gnosia and FMS. FMS, involving either static or dynamic fine finger movement, were examined using 3D motion analyses. Using hierarchical regression, FMS were found to be the best predictor of both cardinality and early arithmetic skills, while finger gnosia did not predict the additional variance of arithmetic performance when FMS and age were considered in the regression model. Moreover, neither finger gnosia nor FMS were significant predictors of enumeration. Mediation analyses indicated that knowledge of the cardinal principle fully mediates the relationship between FMS and arithmetic skills, suggesting that FMS contribute to cardinal principle knowledge development, which would be a gateway to more complex arithmetical processing.