Traditionally, vast health disparities exist in African American populations. Evidence suggests that historically Black college students exhibit high levels of health knowledge; however, it also suggests that this knowledge does not translate into practice. The intent of this research was to explore the general and chronic health knowledge of historically Black college students. Data was collected at an historically Black university through the use of a self-administered survey (n = 428). Univariate, bivariate, and multivariate techniques were used to analyze this data. Overall, it was found that the approximately 75 percent of students exhibited high levels of both general and chronic health knowledge. Through correlation analysis, a positive relationship was found between general health knowledge and gender. (r = 0.194 p = 0.000;). Additionally, a negative correlation was found between chronic health knowledge and major. (r = -0.112 p = 0.034) Due to the exploratory nature of this study, additional research should be conducted to determine if similar results are found in other similar student populations. Efforts should be made to explore other means of increasing the awareness of health related knowledge with students who attend historically Black colleges and universities. (Contains 4 tables.)