Educators and caregivers can foster emotional wellbeing, growth, and resilience, contributing to a fulfilling and balanced adulthood by providing positive childhood experiences (PCEs). PCEs protect the brain and promote healing for people who have experienced adverse childhood environments (ACEs). In the presence of PCEs, adverse experiences in childhood do not always result in lifelong poor mental health. Knowing that PCEs can prevent ACEs, block toxic stress, and promote healing, the HOPE framework incorporates PCEs alongside ACEs. HOPE (Healthy Outcomes from Positive Experiences) is a framework that changes the way service providers engage with children and families. This article examines how the HOPE National Resource Center is transforming systems to create a research-based structured approach to care through PCEs.