Greenberg (2010) is correct in his assertion that the investigational heuristic used to measure the efficacy of antidepressants is flawed. Robust placebo effects are endemic in the psychiatric literature, particularly in studies of antidepressants, and estimates of placebo responding have increased over time (Rief et al., 2009). In the case of established treatments such as antidepressants, the placebo-controlled RCT heuristic is often misapplied (treatments of proven efficacy, no matter how modest, are arguably best understood by comparing their effects with those of other efficacious interventions, not placebos, although we recognize there is not uniformity on this position; see, e.g., Fritze & Moller, 2001). We also agree with Greenberg's (2010) observation that these points, however valid, do nothing to gainsay the argument that prescriptive authority is an appropriate goal for the profession of psychology. We believe that Greenberg (2010) would likely concur with our observation that the profession of psychology, relatively unburdened by questionable ties to pharmaceutical funding sources or biases toward biological interventions, is best positioned to both investigate and apply treatments for mental disorders that optimally combine both pharmacologic and psychotherapeutic approaches.