Physiologically based pharmacokinetic (PBPK) modeling requires an understanding of chemical, physiologic, and pharmacokinetic principles. Active learning with PBPK modeling software (GastroPlus) may be useful to teach these scientific principles while also teaching software operation. To examine this issue, a graduate-level course was designed…

Increasingly, the curricula of many clinical programs have been restructured to an integrated model in which foundational sciences such as physiology, pathophysiology, and pharmacology are taught side by side with clinical reasoning. Case studies are an excellent pedagogical strategy for enhancing such integration, especially if such cases are…

An undergraduate course in pharmacology in which problem-based self-directed learning in the context of small groups provides students with an opportunity to take greater responsibility for their own learning is described. The objectives, examples of problems used in the course, and student evaluations of the course and tutors are included. (KR)