Course-based undergraduate research experience (CURE) exposes an entire class of students to scientific research and is thought to increase students' knowledge retention in science, technology, engineering and mathematics education. Microbial engineering is an interdisciplinary subject that combines science and engineering. We transformed a microbial engineering course into a CURE-type course by adopting an interest-oriented case teaching approach. Based on an investigation of the interest of students, which showed that the topics related to food and health were students' favourites, we selected beer brewing, glutamate fermentation and Monascus cultivation as teaching topics. To simulate the reality of industrial fermentation, pilot-scale fermentation equipment was selected and installed. The course focused on fermentation research; most of the time was spent on performing experiments, and theoretical lectures were held at the intervals. To complete the course in 10 days, three series of experiments were alternatively carried out, and students took turns to conduct fermentation control and process analyses in groups. A questionnaire survey showed that students were satisfied with the CURE-type course, their fermentation knowledge and engineering skills were improved, their research abilities were developed, and their scientific attitudes were cultivated. CURE-type courses are worth popularising in biology teaching.