The data in these tables are collected biennially through the National Science Foundation's (NSF's) Congressionally mandated Survey of Scientific and Engineering Research Facilities. The 1999 survey was sent to research-performing colleges and universities in the United States and to U.S. biomedical research institutions that received National Institutes of Health (NIH) funding in fiscal year 1999. These tables provide data on the status of research facilities needed to conduct science and engineering (S&E) research at U.S. colleges, universities, and nonprofit biomedical research institutions. Data on the amount, quality, adequacy, and condition of S&E research space are presented for the year 1999. Data on the construction and repair/renovation of S&E research facilities and their costs are presented for the years 1998-2001. The historical tables present data for the years 1988-99. Also included are technical notes, lists of institutions, and the survey instrument and accompanying materials. (EV)