Domestic and international competition for STEM talent is driving institutions across the research and innovation landscape to consider new policies and partnerships for building and managing STEM knowledge and skills. New levels of investment in human capital to increase U.S. innovation capacity and competitiveness will require coordination and collaboration among academic institutions, workforce development programs, labor organizations, companies, and funders of research and education. On October 18-19, 2022, the Government-University-Industry Research Roundtable convened a workshop for its membership and invited guests to consider the strategic priority of human capital investment in preparing the future workforce and supporting national innovation capacity. The workshop discussions examined the state of U.S. workforce preparation and considered trends in supply and demand for human capital to meet the needs of a transforming research enterprise. This publication summarizes the presentation and discussion of the workshop. [Paula Whitacre served as rapporteur. Additional contributors include the Government-University-Industry Research Roundtable and Policy and Global Affairs.]