eThese experiments examined the effects of posttrial peripheral and intra-amygdala injections of the cholinergic muscarinic receptor agonist oxotremorine on memory consolidation underlying extinction of amphetamine conditioned place preference (CPP) behavior. Male Long-Evans rats were initially trained and tested for an amphetamine (2 mg/kg) CPP.…

Objective: To compare the rates of physical, psychiatric, and suicide-related events in adolescents with MDD treated with fluoxetine alone (FLX), cognitive-behavioral therapy (CBT), combination treatment (COMB), or placebo (PBO). Method: Safety assessments included adverse events (AEs) collected by spontaneous report, as well as systematic…

Describes project which investigated the effects of computer-assisted instruction (CAI) with pharmacology undergraduates and documented significant instructional interactions, using three treatment groups--CAI, CAI with lecture, and lecture. No significant differences in learning, retention, or attitude toward CAI were found. It was concluded that…

Literature suggests that the factual approach to drug education may cause an increase in drug usage. The pharmacological approach was used in a college drug education course, and an assessment of students' drug consumption was made. No statistically significant changes were found for the substances surveyed. (Author)

A multidisciplinary team, including representatives from medicine, psychology, and residential living, examined 436 mentally retarded residents' regimen of psychotropic medications, with the goal of finding the least restrictive method of behavior management and lowest drug dosage. Significant reductions in psychotropic drug use were observed,…

A study conducted reinforcer assessments for three boys (ages 7-9) with attention deficit hyperactivity disorder who alternately received either a placebo or methylphenidate. Methylphenidate altered the relative reinforcing effectiveness of various stimuli that are often used in classroom-based behavioral treatment programs, particularly coupons…

Individualized assessments of the effects of three dosages of methylphenidate were conducted for two students (ages 10-11) with attention deficit hyperactivity disorder within each child's classroom using behavioral, academic, and social measures. At least one or more dosages were associated with improvement for both children in each area.…

Compares the academic performance of students exposed to either "wet" practical classes or "simulated" practicals. Assessed practical write-ups from pharmacology students using a simulation showed a mark significantly better than those doing the "wet" practical. Simulations can provide an aid to learning which is as effective as "wet" practicals,…

Objective: To determine the long-term safety and effectiveness of risperidone for severe disruptive behaviors in children. Method: A multisite, 1-year, open-label study of patients aged 5 to 14 years with disruptive behaviors and subaverage intelligence was conducted. Results: Seventy-three percent of the 504 patients enrolled completed the study.…

The authors examined the validity of sudden gains identified with T. Z. Tang and R. J. DeRubeis's (1999) method in 2 clinical data sets that involved treatment of major depressive disorder (N=227). Sudden gains replicated among self- and clinician reports of depressive symptoms and predicted better psychosocial functioning at the acute phase…

This review presents the most recent research concerning neuroimaging in developmental disabilities. Changes in structure and activation have been found in children with ADHD and learning disabilities, following intervention. For the children with learning disabilities changes in activation have been found following intensive behavioral and…

The present study examined whether in humans the generalized matching law described the relation between relative responding and relative drug intake by humans under concurrent variable interval variable interval (conc VI VI) schedules of drug reinforcement. Methadone-maintained patients, stabilized on 80 mg per day of methadone, were recruited…

We investigated whether postextinction administration of methylene blue (MB) could enhance retention of an extinguished conditioned response. MB is a redox compound that at low doses elevates cytochrome oxidase activity, thereby improving brain energy production. Saline or MB (4 mg/kg intraperitoneally) were administered to rats for 5 d following…

The return to drug seeking, even after prolonged periods of abstinence, is a defining feature of cocaine addiction. The neural circuitry underlying relapse has been identified in neuropharmacological studies of experimental animals, typically rats, and supported in brain imaging studies of human addicts. Although the nucleus accumbens (NAcc),…

Although published research continues to advocate medication as the first line of treatment for early onset bipolar spectrum disorder (EOBSD; N. Lofthouse & M.A. Fristad, 2004), preliminary research demonstrating the utility of cognitive, cognitive-behavioral, and psychoeducational therapies is promising. It appears as if future treatment of EOBSD…