Background: Data sharing improves the value, synthesis, and integrity of research, but rates are low. Data sharing might be improved if data sharing policies were prominent and actionable at every stage of research. We aimed to systematically describe the epidemiology of data sharing policies across the health research lifecycle. Methods: This was…

Existing systems for automating the assessment of risk-of-bias (RoB) in medical studies are supervised approaches that require substantial training data to work well. However, recent revisions to RoB guidelines have resulted in a scarcity of available training data. In this study, we investigate the effectiveness of generative large language…

The number of clinical prediction models sharing the same prediction task has increased in the medical literature. However, evidence synthesis methodologies that use the results of these prediction models have not been sufficiently studied, particularly in the context of meta-analysis settings where only summary statistics are available. In…

Matching-adjusted indirect comparison (MAIC) enables indirect comparisons of interventions across separate studies when individual patient-level data (IPD) are available for only one study. Due to its similarity with propensity score weighting, it has been speculated that MAIC can be combined with outcome regression models in the spirit of…

Clinical trials registers form an important part of the search for studies in systematic reviews of intervention effectiveness but the search interfaces and functionality of registers can be challenging to search systematically and resource intensive to search well. We report a technical review of the search interfaces of three leading trials…

Population-adjusted indirect comparisons, developed in the 2010s, enable comparisons between two treatments in different studies by balancing patient characteristics in the case where individual patient-level data (IPD) are available for only one study. Health technology assessment (HTA) bodies increasingly rely on these methods to inform funding…

Background: Research coproduction is advocated as an approach to produce more impactful evidence, by valuing a diversity of expertise and integrating knowledge users into research processes. Yet, extant literature finds that trying to bridge boundaries between different types of knowledge can also cause collaboration challenges and present…

Over the last three quarters of a century, international guidelines and regulations have undergone significant changes in how children are problematised as participants in biomedical research. While early guidelines enacted children as vulnerable subjects with diminished autonomy and in need of special protection, beginning in the early 2000s,…

Objective: We examined clinical trial knowledge and attitudes, and their relationship with willingness to participate in COVID-19 vaccine trials, and willingness to accept a COVID-19 vaccine among college students. Participants: 331 undergraduates: mean age 25; 72% women; and 78% white. Methods: We administered an online, anonymous survey to…

To initiate clinical research studies successfully and efficiently, it is critical to develop a strong, feasible, and well-written study protocol early in the start-up phase. The University of Minnesota's Clinical Research Support Center designed and implemented a structured Feasibility Review process in 2018 that addresses common start-up…

When reflecting on my years as a doctoral student, I recall several questions that often came to mind throughout my journey: what is participatory health research? Is such an approach to research truly feasible in the pursuit of a doctoral degree? Is it worth it, or have I inadvertently made things more challenging for myself? My response to these…

Ethnoracial identity refers to the racial and ethnic categories that people use to classify themselves and others. How it is measured in surveys has implications for understanding inequalities. Yet how people self-identify may not conform to the categories standardized survey questions use to measure ethnicity and race, leading to potential…

Systematic reviewers are advised to search trials registers to minimise risk of reporting biases. However, there has been little research on the impact of searching trials registers on the results of meta-analyses. We aimed to evaluate the impact of searching clinical trials registers for systematic reviews of pharmaceutical or non-pharmaceutical…

Hospitals serve as a public space for medical practice. They also serve as an educational space. Effective, transparent, and timely delivery of health information is important at all times but especially in times of pan/epidemics. A crucial part of the necessary information dissemination is language-in-use for multiple purposes (medical practice,…

In Jordan, research ethics committees exist in most health settings. However, little is known about Jordanian public views regarding the ethics of clinical research. This study aimed to evaluate Jordanian public understanding and attitudes about ethics in clinical research. A questionnaire was used to collect information that included…