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Weible, Aldis P.; Oh, M. Matthew; Lee, Grace; Disterhoft, John F. – Learning & Memory, 2004
Cholinergic systems are critical to the neural mechanisms mediating learning. Reduced nicotinic cholinergic receptor (nAChR) binding is a hallmark of normal aging. These reductions are markedly more severe in some dementias, such as Alzheimer's disease. Pharmacological central nervous system therapies are a means to ameliorate the cognitive…
Descriptors: Conditioning, Animals, Eye Movements, Pharmacology
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Spencer, Thomas J.; Faraone, Stephen V.; Biederman, Joseph; Lerner, Marc; Cooper, Kimberly M.; Zimmerman, Brenda – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To investigate whether prolonged therapy with a long-acting stimulant affects growth in children with attention-deficit/hyperactivity disorder (ADHD). Method: One hundred seventy-eight children ages 6 to 13 years received OROS methylphenidate (OROS MPH, CONCERTA) for at least 21 months. Height and weight were measured monthly during the…
Descriptors: Body Height, Body Weight, Drug Therapy, Stimulants
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McGough, James; McCracken, James; Swanson, James; Riddle, Mark; Kollins, Scott; Greenhill, Laurence; Abikoff, Howard; Davies, Mark; Chuang, Shirley; Wigal, Tim; Wigal, Sharon; Posner, Kelly; Skrobala, Anne; Kastelic, Elizabeth; Ghuman, Jaswinder; Cunningham, Charles; Shigawa, Sharon; Moyzis, Robert; Vitiello, Benedetto – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: The authors explored genetic moderators of symptom reduction and side effects in methylphenidate-treated preschool-age children diagnosed with attention-deficit/hyperactivity disorder (ADHD). Method: DNA was isolated from 81 subjects in a double-blind, placebo-controlled, crossover methylphenidate titration. Parents and teachers…
Descriptors: Hyperactivity, Genetics, Attention Deficit Disorders, Drug Therapy
Mergener, Michael A. – Mobius: A Journal for Continuing Education Professionals in Health Sciences, 1981
This study compares the scores optometrists obtained on a pharmacology examination with years since licensure and type of continuing education participation preceding the examination. Recent licensees scored better than those licensed before 1953. Continuing education activity also promoted better scores. (CT)
Descriptors: Continuing Education, Optometrists, Pharmacology, Professional Continuing Education
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Hollon, Steven D.; And Others – Journal of Consulting and Clinical Psychology, 1991
Reviews use of cognitive therapy (CT) for depression compared to use of tricyclic pharmacotherapy in nonbipolar outpatients. Suggests that CT may be roughly comparable in treatment of the acute episode, combined CT-pharmacotherapy does not appear to be clearly superior to either modality, and CT treatment during the acute episode may reduce the…
Descriptors: Cognitive Restructuring, Depression (Psychology), Drug Therapy, Outcomes of Treatment
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Jones, Katherine R.; Fink, Regina; Pepper, Ginny; Hutt, Eveyln; Vojir, Carol P.; Scott, Jill; Clark, Lauren; Mellis, Karen – Gerontologist, 2004
Purpose: Effective pain management remains a serious problem in the nursing home setting. Barriers to achieving optimal pain practices include staff knowledge deficits, biases, and attitudes that influence assessment and management of the residents' pain. Design and Methods: Twelve nursing homes participated in this intervention study: six…
Descriptors: Pharmacology, Intervention, Allied Health Personnel, Nursing Homes
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Short, Elizabeth J.; Manos, Michael J.; Findling, Robert L.; Schubel, Emily A. – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: The purpose of this study was to examine the efficacy of psychostimulant medication in a naturalistic sample of preschoolers. Benefits and side effects for methylphenidate and mixed amphetamine salts (Adderall) were examined. Method: Twenty-eight preschoolers (ages 4.0-5.9) participated in the present investigation. They were obtained…
Descriptors: Psychiatry, Pharmacology, Stimulants, Preschool Children
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Sporn, Alexandra L.; Bobb, Aaron J.; Gogtay, Nitin; Stevens, Hanna; Greenstein, Deanna K.; Clasen, Liv S.; Tossell, Julia W.; Nugent, Thomas; Gochman, Peter A.; Sharp, Wendy S.; Mattai, Anand; Lenane, Marge C.; Yanovski, Jack A.; Rapoport, Judith L. – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: Weight gain is a serious side effect of atypical antipsychotics, especially in childhood. In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment. Method: Fasting serum samples for 24 patients with COS and 21 matched healthy controls…
Descriptors: Psychiatry, Patients, Schizophrenia, Obesity
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Salt, Alec N. – Volta Review, 2005
The inner ear is exposed to aminoglycosides or other drugs either intentionally or as a side effect of clinical treatments directed at other regions of the body. An understanding of the effects of drugs on the inner ear requires knowledge of the pharmacokinetics of the drug once it reaches the cochlear fluids, specifically how much of it reaches…
Descriptors: Hearing Impairments, Pharmacology, Human Body, Drug Therapy
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Talaska, Andra E.; Schacht, Jochen – Volta Review, 2005
The search for protection from aminoglycoside ototoxicity is nearly as old as their use as antibiotics. However, only in recent years has focused research on the mechanisms underlying the insults to the inner ear led to coherent attempts at protection, such as antioxidant therapy or interference with cell death signaling pathways. Successful…
Descriptors: Outcomes of Treatment, Pharmacology, Drug Therapy, Hearing Impairments
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Glick, Ira D.; Zisook, Sidney – Academic Psychiatry, 2005
Objective: For a variety of pedagogical, political and financial reasons, there are major problems in achieving effective teaching of cutting-edge psychopharmacology for psychiatric residents. This article focuses on ways to improve the teaching/learning process, in part through the use of structured curricula. The authors review 1) attempted…
Descriptors: Pharmacology, Curriculum, Role, Educational Improvement
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Carlson, John S.; Demaray, Michelle Kilpatrick; Hunter-Oehmke, Shana – Psychology in the Schools, 2006
A national sample of 320 school-based, practicing members of the National Association of School Psychologists provided information on (a) their caseloads receiving medications, (b) types of school psychopharmacology training opportunities available and perceptions of their current training in child psychopharmacology, and (c) information about…
Descriptors: Pharmacology, School Psychologists, Independent Reading, Educational Opportunities
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Sallee, Floyd R.; Miceli, Jeffrey J.; Tensfeldt, Thomas; Robarge, Lisa; Wilner, Keith; Patel, Nick C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2006
Objective: The purpose of this study was to provide single-dose pharmacokinetic, safety, and tolerability data for ziprasidone in youths with tic disorder, for comparison to adult studies to discern whether ziprasidone pediatric dosing could be modeled from adult data. Method: A single-dose, open-label study of ziprasidone was conducted in youths…
Descriptors: Safety, Pharmacology, Children, Drug Therapy
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Pliszka, Steven R.; Matthews, Thomas L.; Braslow, Kenneth J.; Watson, Melissa A. – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To determine whether methylphenidate (MPH) and mixed salts amphetamine (MSA) have different effects on growth in children with attention-deficit/hyperactivity disorder. Method: Patients treated for at least 1 year with MPH or MSA were identified. A linear regression was performed to determine the effect of stimulant type, patient…
Descriptors: Attention Deficit Disorders, Children, Stimulants, Hyperactivity
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Egan, Kelly J.; And Others – Journal of Consulting and Clinical Psychology, 1988
Administered intravenous infusions to phobic patients prior to systematic desensitization. Saline-infused subjects significantly demonstrated the predicted symptom decrease in response to systematic desensitization, whereas naloxone-infused subjects showed no change. Subject reports and psychophysiological measures of arousal indicated no…
Descriptors: Arousal Patterns, Behavior Modification, Desensitization, Drug Therapy
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