The development of professional skills is essential for biology students to be successful in their future careers. However, current teaching approaches often fail to provide adequate training. The aim of this theory to practice study was to develop an effective methodology for improving the professional skills of biology students through laboratory work. Theoretical and diagnostic methods, mathematical statistics, empirical methods, and a questionnaire were used. The results showed a significant increase in competencies after the laboratory training intervention. Students demonstrated significant improvements in technical skills, critical thinking, teamwork, and communication. In conclusion, structured practical laboratory training shows promise for enhancing the professional capabilities of aspiring biologists. The practical value of this study is to develop work skills, independent decision-making ability, and professional skills, in line with the requirements of modern scientific community.