Objective: To determine the differences in internalizing symptoms between those who met criteria for Cannabis Use Disorder (CUD) and those who did not in young adults attending a Historically Black College or University (HBCU). Participants: The sample included 619 undergraduate students, with 110 (18%) who met criteria for CUD. Methods: Participants completed an online survey, which included demographic, anxious and depressive symptomatology, and substance use assessment. Results: Those who met CUD criteria reported more depressive symptoms (M = 22.83 [plus or minus] 10.74) and anxiety symptoms (M = 45.70 [plus or minus] 12.82) than their non-CUD counterparts (M = 19.17 [plus or minus] 10.58; M = 40.57 [plus or minus] 14.11, respectively). Conclusion: Differences between those who met criteria for CUD and those who did not are consistent with previous literature and may aid in characterizing internalizing behaviors in HBCU students with CUD. Future research should examine the subgroups that may cycle through withdrawal symptoms, despite not having severe CUD. This subgroup may be at higher risk for psychopathology than their severe counterparts.