Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional…

Purpose: The larynx is a uniquely situated organ, juxtaposed between the gastrointestinal and respiratory tracts, and endures considerable immunological challenges while providing reflexogenic responses via putative mucosal mechanoreceptor afferents. Laryngeal afferents mediate precise monitoring of sensory events by relay to the internal branch…

Using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated DNA methylation changes in CA1 hippocampus of Sprague-Dawley rats specific to threat learning at genes involved in synaptic transmission. Experience-dependent alternations in gene expression and DNA methylation were observed as early as 1 h…

Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and behavioral data from a mouse population designed to model human variation in cognitive outcomes to…

Spatial working memory (SWM) is the ability to encode, maintain, and retrieve spatial information over a temporal gap, and relies on a network of structures including the medial septum (MS), which provides critical input to the hippocampus. Although the role of the MS in SWM is well-established, up until recently, we have been unable to use…

On-farm bacteriologic culturing (OFBC) provides quick and inexpensive mastitis diagnosis, but commercial adoption of this innovation has been low in Mississippi. We implemented an Extension-led trialing program to identify reasons for producers' lack of OFBC adoption, explore change in producers' knowledge and perceptions of OFBC, and assess the…

The world is changing: both a conventional and a vaccine passport are now needed to travel internationally. Mask mandates, and social distancing are the new norm in a rapidly changing society. These measures were put in place to control the spread of the highly infectious and often fatal COVID-19, caused by a viral agent, a microorganism, a…

We examined risk perceptions that aquatic-based recreation stakeholders in the Great Lakes region held about fish diseases, using viral hemorrhagic septicemia (VHS) as our case study. Eighty-five percent of study participants knew nothing or very little about VHS. Regarding risks posed by VHS, participants overall were most concerned about risks…

Bovine respiratory disease (BRD) is an often unrecognized problem in cow-calf herds. We describe a program we used to help producers identify and avoid practices that could increase their herds' risk for BRD. The greatest knowledge gains occurred for the topics of costs associated with BRD, BRD risks at the feedlot, and biosecurity measures.…

Research has shown that animal-assisted activities have specific benefits for older adults, such as decreasing loneliness (Banks & Banks, 2002; Banks, Willoughby, & Banks, 2008; Calvert, 1989) and depression (Grubbs, Artese, Schmitt, Cormier, & Panton, 2016; Le Roux & Kemp, 2009; Moretti et al., 2010) while increasing positive…

The objectives of the study on which this paper is based, were to develop an IT [Information Technology] based expert system on dairy cattle diseases for Continuing Veterinary Education (CVE) of veterinarians and to assess its effectiveness. The veterinarians working in three districts under the Animal Husbandry Department, Kerala were the…

This article is devoted to the problem of veterinary safety of the countries under the Eurasian Economic Union. Animal health's measures are provided in order to prevent the entry and spread of infectious animal diseases, including common to humans and animals, as well as goods not conforming to the common veterinary and sanitary requirements.…

One of the overlapping curriculum designs indicates the mismatch of teaching materials with the cognitive level process and student development, impacting the unstructured qualification of mastery of the material. On the other hand, the breadth and depth of teaching materials in the curriculum must be following students' mental development and…

The Roma people are the largest stateless population in Central and Eastern (CEE) Europe and face a disproportionate amount of environmental health disparities likely due to a long history of discrimination and stigmatization. Using qualitative research methodology and community-based participatory research methods, we aimed to gain a more nuanced…

Background: Research on biosecurity is important as New Zealand's agricultural export-driven economy is susceptible to biosecurity threats. Because New Zealand is reliant on the primary industries to drive its economy, bovine diseases such as foot and mouth could have a devastating effect on the economy. Purpose: Making sure that the general…