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A Neuroimaging Proof of Principle Study of Down's Syndrome and Dementia: Ethical and Methodological Challenges in Intrusive Research
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d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H. – Journal of Intellectual Disability Research, 2013
Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…
Descriptors: Down Syndrome, Dementia, Ethics, Neurological Impairments
Theoretical Exploration of the Neural Bases of Behavioural Disinhibition, Apathy and Executive Dysfunction in Preclinical Alzheimer's Disease in People with Down's Syndrome: Potential Involvement of Multiple Frontal-Subcortical Neuronal Circuits
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Ball, S. L.; Holland, A. J.; Watson, P. C.; Huppert, F. A. – Journal of Intellectual Disability Research, 2010
Background: Recent research has suggested a specific impairment in frontal-lobe functioning in the preclinical stages of Alzheimer's disease (AD) in people with Down's syndrome (DS), characterised by prominent changes in personality or behaviour. The aim of the current paper is to explore whether particular kinds of change (namely executive…
Descriptors: Mental Retardation, Alzheimers Disease, Diseases, Personality
The Modified CAMDEX Informant Interview is a Valid and Reliable Tool for Use in the Diagnosis of Dementia in Adults with Down's Syndrome
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Ball, S. L.; Holland, A. J.; Huppert, F. A.; Treppner, P.; Watson, P.; Hon, J. – Journal of Intellectual Disability Research, 2004
Dementia because of Alzheimer's disease (AD) commonly affects older adults with Down's syndrome (DS). Methods are needed, with established concurrent and predictive validity, to facilitate the diagnostic assessment of dementia, when it is complicated by pre-existing intellectual disabilities (ID). We report on the reliability and validity of a…
Descriptors: Identification, Predictive Validity, Interrater Reliability, Alzheimers Disease