This is a fundamental and pedagogical work in quantum physics/chemistry, where we try to illustrate the Mulliken's question, "What are the electrons really doing in molecules?". And we also briefly review the development of the most popular numerical approaches in computational chemistry. We examine in a novel approach, how we can…

The epigenome serves as a signal integration platform that encodes information from experience and environment that adds tremendous complexity to the regulation of transcription required for memory, beyond the directions encoded in the genome. To date, our understanding of how epigenetic mechanisms integrate information to regulate gene expression…

Acid-base chemistry, and in particular the Lewis acid-base model, is foundational to understanding mechanistic ideas. This is due to the similarity in language chemists use to describe Lewis acid-base reactions and nucleophile-electrophile interactions. The development of artificial intelligence and machine learning technologies has led to the…

Introductory chemistry textbooks often present valence bond (VB) theory as useful, but incorrect and inferior to molecular orbital (MO) theory, citing the electronic structure of O[subscript 2] and electron delocalization as evidence. Even texts that initially present the two theories on equal footing use language that biases students toward the…

We present the use of an oxygen tolerant controlled radical polymerization (photoinduced electron/energy transfer-reversible addition fragmentation chain transfer polymerization, PET-RAFT) as a simple method for preparing controlled radical polymers in an undergraduate laboratory. Unlike conventional techniques, PET-RAFT polymerizations require no…

Powerful arguments have been made recently to advocate for the introduction of systems thinking in chemistry education to equip graduates to address sustainability challenges. This contribution describes systems thinking activities and an assessment tool that enables meaningful learning in first-year organic chemistry as students engage with the…

Understanding the relationship between protein structure and function can be challenging for students. Molecular visualization software aids students in this problem by allowing manipulation of structures from new and deeper perspectives. In this communication, an activity using iMolview Lite, structure visualization software for portable devices,…

This article argues that we need to make use of our everyday experiences when introducing concepts in chemistry that are often obscure. It uses reaction rates as an example and explores a common misconception related to the explanation of the effect of rising temperature on the rate of slow reactions.

Physical and life science disciplines emphasize how basic structural units influence function, yet it is challenging for students to understand structure-function relationships, particularly at molecular scales. Undergraduates in our biology capstone course struggled to connect mutations in a gene encoding a key protein in a cell development…

Nuclear magnetic resonance (NMR) spectroscopy has become a cornerstone tool for studying a variety of molecular features in advanced chemistry laboratories. In this experiment, students prepare a pyrrole-[beta]-amide via a one-pot, three-step synthesis and use NMR spectroscopy to confirm its molecular structure. In addition, variable temperature…

One of the more difficult concepts introduced in the first-year undergraduate course, general chemistry, is that of chirality. Typically, left and right hands are the common, macroscopic objects of reference used to demonstrate the quality of being nonsuperimposable, followed by the use of a mirror and molecular models, to illustrate molecular…

Biology is a data-driven discipline facilitated greatly by computer programming skills. This article describes an introductory experiential programming activity that can be integrated into distance learning environments. Students are asked to develop their own Python programs to identify the nature of alleles linked to disease. This activity…

An application for visualizing the dynamic properties of an equimolar binary mixture of isotropic reactive particles is presented. By introducing a user selectable choice for the activation energy, the application is useful to demonstrate qualitatively that the reaction rate depends on the above choice and on temperature. The application is based…

The authors describe the construction and use of tactile models for demonstrating intermolecular forces. These models are composed of inexpensive materials and can be used in college chemistry classrooms of varying levels including general and organic chemistry. The models were designed to be paired with an accompanying activity to encourage…

A simple one-dimensional [superscript 1]H NMR experiment that quantifies protein bound to gold nanoparticles has been developed for upper-division biochemistry and physical chemistry students. This laboratory experiment teaches the basics of NMR techniques, which is a highly effective tool in protein studies and supports students to understand the…