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Direct linkDommett, Eleanor J.; Henderson, Emma L.; Westwell, Martin S.; Greenfield, Susan A. – Learning & Memory, 2008
Methylphenidate treatment is used for Attention Deficit Hyperactivity Disorder and can improve learning and memory. Previously, improvements were considered a by-product of increased attention; however, we hypothesize that methylphenidate directly alters mechanisms underlying learning and memory, and therefore examined its effects on hippocampal…
Descriptors: Hyperactivity, Attention Deficit Disorders, Memory, Depression (Psychology)
Miller, Courtney A.; Sweatt, J. David – Learning & Memory, 2006
Post-retrieval interference with a memory has uncovered a phenomenon known to the field as reconsolidation. In this article, we will review the specific molecular mechanisms that have been implicated in reconsolidation. As a result of numerous studies over the past five years, it can now be said with a fair amount of certainty that reconsolidation…
Descriptors: Science Experiments, Molecular Biology, Neurology, Learning Processes
Sossin, Wayne S. – Learning & Memory, 2007
Protein kinase Cs (PKCs) are implicated in many forms of synaptic plasticity. However, the specific isoform(s) of PKC that underlie(s) these events are often not known. We have used "Aplysia" as a model system in order to investigate the isoform specificity of PKC actions due to the presence of fewer isoforms and a large number of documented…
Descriptors: Biochemistry, Molecular Biology, Physiology, Structural Analysis (Science)
Miller, Ralph R.; Matzel, Louis D. – Learning & Memory, 2006
For at least 40 years, there has been a recurring argument concerning the nature of experimental amnesia, with one side arguing that amnesic treatments interfere with the formation of enduring memories and the other side arguing that these treatments interfere with the expression of memories that were effectively encoded. The argument appears to…
Descriptors: Data Interpretation, Convergent Thinking, Recall (Psychology), Retention (Psychology)
O'Carroll, Colin M.; Martin, Stephen J.; Sandin, Johan; Frenguelli, Bruno; Morris, Richard G. M. – Learning & Memory, 2006
The persistence of new memory traces in the hippocampus, encoded following appropriate activation of glutamatergic receptors and the induction of synaptic plasticity, can be influenced by heterosynaptic activation of neuromodulatory brain systems. We therefore investigated the effects of a hippocampus-specific blockade of dopamine D1/D5 receptors…
Descriptors: Intervals, Brain, Animals, Animal Behavior
Reyes, Fredy D.; Mozzachiodi, Riccardo; Baxter, Douglas A.; Byrne, John H. – Learning & Memory, 2005
In a recently developed in vitro analog of appetitive classical conditioning of feeding in "Aplysia," the unconditioned stimulus (US) was electrical stimulation of the esophageal nerve (En). This nerve is rich in dopamine (DA)-containing processes, which suggests that DA mediates reinforcement during appetitive conditioning. To test this…
Descriptors: Reinforcement, Logical Thinking, Operant Conditioning, Classical Conditioning
