Building bridges among education stakeholders is an important but underused strategy for creating a culture in which professional learning is seen as a shared responsibility. The National Center for School-University Partnerships, headquartered at the University of Mississippi, has embraced improvement science as a core strategy in its bridge-building work. Improvement science provides a structured, evidence-based approach to solving problems of practice and achieving sustainable improvements. This article outlines how the center applies six core improvement science principles to build sustainable professional learning partnerships and shares examples of this work in action.