A sentence is an important unit in English language, and plays a crucial role in language teaching and learning as well. For many years, sentence teaching is always worth discussion in English teaching, because sentence imitation is very important for students' construction of logical discourse. This paper, based on memetics, proposes some certain optimization strategies of sentence imitation in primary school English teaching from the perspective of strong memes, and points out that efficient sentence imitation is of great importance in primary school English teaching.