The Personal Responsibility Education Program (PREP), authorized by Congress in 2010, is one of the largest federally funded programs designed to prevent adolescent pregnancy and sexually transmitted infections and prepare youth for successful transition to adulthood. PREP legislation requires grantees to incorporate into their programs content on a minimum of three of six adulthood preparation subjects (APSs): adolescent development, educational and career success, financial literacy, healthy life skills, parent-child communication, and healthy relationships. In 2017-2018, healthy relationships was the most commonly addressed APS topic (96 percent) and financial literacy was the least commonly addressed APS topic by PREP grantees (21 percent) as reported in PREP performance measure data. This brief offers guidance to PREP grantees on how to address financial literacy in their programming. Sections of the brief provide a working definition for financial literacy, highlight the importance of delivering content that is timely, relevant, and developmentally appropriate for youth, and offer guidance on how grantees can build on topics sequentially as youth age. The brief also discusses how programs can align financial literacy programming with the needs of youth from diverse backgrounds and experiences.