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Direct linkShy, Michael E.; Jani, Agnes; Krajewski, Karen; Grandis, Marina; Lewis, Richard A.; Shy, Rosemary R.; Balsamo, Janne; Lilien, Jack; Garbern, James Y.; Kamholz, John – Brain, 2004
Myelin protein zero (MPZ) is a member of the immunoglobulin gene superfamily with single extracellular, transmembrane and cytoplasmic domains. Homotypic interactions between extracellular domains of MPZ adhere adjacent myelin wraps to each other. MPZ is also necessary for myelin compaction since mice which lack MPZ develop severe dysmyelinating…
Descriptors: Neurological Impairments, Genetics, Brain, Patients
Hickman, S. J.; Toosy, A. T.; Jones, S. J.; Altmann, D. R.; Miszkiel, K. A.; MacManus, D. G.; Barker, G. J.; Plant, G. T.; Thompson, A. J.; Miller, D.H. – Brain, 2004
In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination. This study followed serial changes in MTR in acute optic neuritis in combination with clinical and electrophysiological measurements to determine if the MTR…
Descriptors: Brain, Neurological Impairments, Visual Impairments, Diseases
Grossman, Murray; McMillan, Corey; Moore, Peachie; Ding, Lijun; Glosser, Guila; Work, Melissa; Gee, James – Brain, 2004
Confrontation naming is impaired in neurodegenerative conditions like Alzheimer's disease (AD), frontotemporal dementia (FTD) and corticobasal degeneration (CBD). Some behavioural observations suggest a common source of impaired naming across these patient groups, while others find partially unique patterns of naming difficulty. We hypothesized…
Descriptors: Brain, Dementia, Neurological Impairments, Alzheimers Disease
